In this presentation we will demonstrate our flexible microneedle electrochemical probes based on biomimetric redox responsive composite hydrogels for in-situ multiplex detection of biologically relevant chemical markers, e.g., redox biomarkers, pH, biogenic amines, antioxidants, lactate, cortisol, and adrenaline. The composite hydrogels in these sensors simultaneously serve as an interface for biological fluid sampling and a medium for electrochemical sensing. Our presentation will demonstrate our e-skin sensory devices for real-time wireless monitoring of on-plant stress diagnostics, on-packaging food spoilage analytics, and wearable ‘emotion’ sensing in humans. In all cases, the sensors utilize non-invasive biological fluids, e.g., sweat and interstitial fluids for animals, and plants apoplastic exudates. The wearable sensors are aimed for applications in precision agri-food &nutrition, and health&wellness monitoring.